Testosterone Protocol

How it works

Enclomiphene, the active ingredient in Testosterone Protocol, blocks estrogen receptors and treats long-term hypogonadism (low testosterone).

Enclomiphene citrate is the purified isomer of Clomid (Clomiphene Citrate), which has been FDA approved since 1967 for fertility in women, and has been commonly used off-label in men. Research studies suggest Clomid “is safe and effective with few side effects when used as long-term treatment of hypogonadism (low testosterone)” and is an “effective and safe alternative to testosterone supplementation in [young] men wishing to preserve their fertility.”

Testosterone Protocol

enclomiphene

How the dosage is optimized

01
Establish health needs and goals
Fill out a medical questionnaire to establish your goals, which are reviewed by a board-certified licensed physician.
02
Test your testosterone levels
CLIA-certified lab tests are shipped to your door so you and your doctor can monitor your testosterone levels before and after starting treatment. We collect blood (without finger pricking) just before beginning the medication to establish a clean baseline.
03
Customize your treatment plan
Based on your health goals and current testosterone levels, your doctor will prescribe a treatment plan that best fits your needs.
04
Re-test your testosterone levels
After 30 days, you’ll receive another CLIA-certified lab test to see if the protocol is working for you.
05
Monitor your progress
You’ll never be left on your own. Your doctor will continue to review and optimize your dosage every 30 days. If you don’t see an increase in your testosterone levels, we’ll refund your money.

What our testosterone test measures

Testosterone optimization demands customization.

There’s no one-size-fits-all approach, which is why the Maximus program evaluates your hormone levels as well as how you feel and function to determine what your appropriate levels should be. This allows us to treat symptoms, not numbers.

Maximus vs. Everlywell testosterone test

Maximus

Everlywell

Testing is part of the Testosterone Protocol, which also includes prescription medication of enclomiphene citrate and health coaching

Medication is prescribed separately and not part of a specific protocol

No finger pricking

Finger pricking

Testing performed before and after taking medication to establish a baseline and monitor progress

Testing only performed once

Pairs you with a doctor to go over results and customize a treatment plan

You are encouraged to discuss results with your own healthcare provider, though you will receive general recommendations based on your levels

Natural vs synthetic testosterone

Testosterone Protocol stimulates your own natural testosterone production.

Since you continue to produce your own natural testosterone, if you decide to stop treatment your body will most likely return to the level it was before treatment.

TRT replaces your testosterone with synthetic testosterone.

When in treatment, the body stops making its own natural testosterone. If/when therapy ends their body's natural testosterone production most likely will not fully recover.

Maximus Testosterone ProtocolNatural testosterone

Testosterone Replacement Therapy (TRT)Synthetic testosterone

Testosterone: increased by 1.5-2.5X, proven by lab tests

Testicles: maintains your size, function, & fertility.*

Hair: doesn't increase DHT:T ratio, minimal side effects.*

Application: easy to take oral or sublingual tablets, no injectables or messy creams

Eligibility: doctor assessment is on symptoms, not just low testosterone

Enclomiphene vs. Other Treatments

Unlike Clomid, which is made up of 38% zuclomiphene and 62% enclomiphene, Testosterone Improvement Protocol will not increase estrogen or cause side effects like mood swings, enlarged breasts, and libido issues because it does not contain zuclomiphene. Zuclomiphene is an estrogen receptor agonist (increases estrogen) that stays in your system a long time and accumulates much more over time than enclomiphene.

And the research shows most of the beneficial effects of clomiphene are due to the enclomiphene, with zuclomiphene “contributing little to the intended outcomes.” Maximus’ cutting-edge innovation leverages purified Clomid to maximize the amount of enclomiphene present, thus maintaining the androgenic benefit of clomiphene citrate without the undesirable effects attributable to zuclomiphene. Increased testosterone levels are achieved while maintaining sperm concentration (unlike TRT).

Zuclomiphene vs Enclomiphine Build-Up In Blood Stream

25mg/Day Clomiphene Dosage

Fig.1 - Huang ES, Miller WL. Estrogenic and antiestrogenic effects of enclomiphene and zuclomiphene on gonadotropin secretion by ovine pituitary cells in culture. Endocrinology. 1983;112(2):442-8.

Unlike TRT, which replaces your testosterone synthetically, enclomiphene increases your natural testosterone production. As a Selective Estrogen Receptor Modulator (SERM), enclomiphene blocks estrogen, tricking the brain into producing the hormones luteinizing hormone (LH) and Follicle Stimulating Hormone (FSH). This inadvertently increases the testes production of testosterone and sperm, respectively, giving your testosterone a 1.5-2.5x boost without the testicular shutdown, shrinkage, infertility, and dependence of dated alternatives.

Studies comparing enclomiphene for testosterone restoration vs. testosterone gel for TRT show why this approach is superior in individuals who still have normal testicular function. In obese, hypogondal (low T) men, enclomiphone increases testosterone more than testosterone gel and keeps levels more consistently stable.

Clinical Trials with SERMs

Patients who took 6.25 - 25 mg of a SERM increase testosterone levels by 1.5 - 2.5 % with minimal side effects

Fig.2 - Need

Zuclomiphene vs Enclomiphine Build-Up In Blood Stream

25mg/Day Clomiphene Dosage

Fig.1 - Huang ES, Miller WL. Estrogenic and antiestrogenic effects of enclomiphene and zuclomiphene on gonadotropin secretion by ovine pituitary cells in culture. Endocrinology. 1983;112(2):442-8.

Clinical Trials with SERMs

Patients who took 6.25 - 25 mg of a SERM increase testosterone levels by 1.5 - 2.5 % with minimal side effects

Fig.2 - Need

Clinical results

Studies using enclomiphene for testosterone restoration vs. TRT also show that while both testosterone treatments increase testosterone, enclomiphene does not negatively impact sperm production like TRT.

Testosterone Improvement during treatment

Fig.3 - Kim ED, McCullough A, Kaminetsky J. Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement. BJU Int. 2016;117(4):677-85.

While enclomiphene enhances how the body naturally and endogenously produces testosterone and sperm, TRT significantly impairs LH and FSH production. This inhibits the endogenous production of testosterone and sperm, causing testicular shrinkage and external dependence on testosterone gel.

TRT vs Enclomiphene Clinical Results on Sperm Concentration

Fig.4 - Earl JA, Kim ED. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism. Expert Rev Endocrinol Metab. 2019;14(3):157-65.

Enclomiphene works by supporting the body's natural production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which are essential for making testosterone and sperm. This means it helps maintain healthy sperm quality and keeps testicular size normal. On the other hand, traditional testosterone replacement therapies (TRTs) can interfere with this balance, sometimes reducing sperm production and causing testicular shrinkage.

TRT vs Enclomiphene Clinical Results on FSH/LH levels

Fig.5 - Kim ED, McCullough A, Kaminetsky J. Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement. BJU Int. 2016;117(4):677-685. doi:10.1111/bju.13337

Drug facts

Ingredient

enclomiphene

How it works

Experience a 1.5-2.5X testosterone boost without the testicular shutdown, shrinkage, infertility, and dependence of dated alternatives.* Learn more about enclomiphine.

Testosterone Restoration

Unlike TRT, which shuts down your body's production of testosterone, this protocol blocks estrogen receptors and increases your testosterone through natural stimulation.

Drug Facts

Serving size:

1 tablet a day

Per bottle:

30 tablets

Application:

Oral or sublingual

Enclomiphene:

3.125 - 25mg

Pregnenolone

5-20mg

Minimal side effects

The adverse effects of enclomiphene have been extensively studied during phase II and phase III clinical trials. The drug is generally well tolerated with side effects occurring relatively rarely.

Side effects

% of patients

Headache:

3.3%

Common Cold:

1.7%

Nausea:

2.1%

Hot flush:

1.7%

Diarrhea:

1.9%

Joint pain:

1.2%

Dizziness: