The Maximus Guide to Enclomiphene Dosing
Enclomiphene dosing is not one-size-fits-all. Your labs set it.
A doctor reads your blood work, sets your first dose, then adjusts it.
See if you qualify →The short answer: doctors start low and move with your labs
Enclomiphene is a once-daily oral tablet. In the Maximus Enclomiphene Protocol Study (N=1,250), starting doses were 3.125mg, 6.25mg, or 12.5mg, and doctors titrated up to 25mg.
Your own starting dose comes from your markers, your symptoms, and your goals. So does every change. There is no number to look up here: your doctor sets your starting dose, and it varies from one man to the next.
At a glance
Oral, once a day, labs at the start and at 4 weeks
Enclomiphene key facts
- Route
- Oral tablet
- Frequency
- Once a day
- Dose levels in the N=1,250 study
- 3.125mg, 6.25mg, 12.5mg, up to 25mg
- Half-life
- About 10 hours
- First lab recheck
- 3 to 4 weeks after a dose change
- Time to full effect
- 1.5 to 2 months
- Ongoing
- Doctor feedback every 3 months. Labs every year.
What the study measured
The study used four dose levels, not one standard dose
In the Maximus Enclomiphene Protocol Study (N=1,250), mean free testosterone rose 67.0% at 6.25mg and 150.3% at 12.5mg. Above 12.5mg the study did not report a further rise.
Only a doctor can set your dose. What follows is what the study measured at each level, not a plan you can run on your own.
| Dose | What the N=1,250 study reported |
|---|---|
| 3.125mg once daily | One of the study's three starting doses. The study reported no separate response figure at this level. |
| 6.25mg once daily | Mean free testosterone rose 67.0% |
| 12.5mg once daily | Mean free testosterone rose 150.3%. Top of the range where more dose produced more response. |
| 25mg once daily | The upper dose in the study. A physician sets it, case by case. |
NOT DOSING INSTRUCTIONS
The dose levels on this page describe what physicians prescribed inside a Maximus study. They are not a dosing recommendation, a starting-dose instruction, or a titration schedule for any individual. Enclomiphene is a prescription medication. Only a licensed physician who has reviewed your blood work and your medical history can set or change your dose. Do not use this page to start, stop, or adjust a medication.
Compounded medications are not FDA-approved for safety, efficacy, or quality.
Study sources and what the figures mean
Source: Maximus Enclomiphene Protocol Study, N=1,250, a retrospective observational study of real-world telemedicine data with no placebo control. Figures are group means and group proportions, not per-client outcomes. Mean free testosterone rose 89.7% and mean total testosterone rose 81.8% across the full study population (p < 0.001). At the dose level reported, mean free testosterone rose 67.0% at 6.25mg and 150.3% at 12.5mg. The mean is the generally expected result. Individual results vary, and some men respond less than the mean. Full study: maximustribe.com/white-paper/enclomiphene
Enclomiphene has an elimination half-life of about 10 hours, with peak levels about 4 hours after a dose. Source: Wiehle RD, Fontenot GK, Wike J, Hsu K, Nydell J, Lipshultz L; ZA-304 Trial Investigators. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU Int. 2013;112(8):1188-1200. doi:10.1111/bju.12363 (citation 07).
N=45 Topical T + Enclomiphene Study figures apply only to Testosterone Cream paired with enclomiphene at 12.5mg or higher. They are not standalone enclomiphene findings. Full study: maximustribe.com/white-paper-testosterone-cream
FDA's approved indication for testosterone products is classical or organic hypogonadism. FDA retained a Limitation of Use explicitly warning that the safety and efficacy of testosterone products have not been established for men with age-related hypogonadism.
Maximus protocols are designed to address those challenges for men whose labs confirm suboptimal levels.
How the dose changes
Your markers decide the next dose
A Maximus doctor sets enclomiphene dosage from three inputs: your testosterone levels, your symptoms, and your goals. After a change, you retest. The study collected follow-up blood 3 to 4 weeks after each dose change, and Maximus retests at 4 weeks.
In that study, the share of men with total testosterone above 300 ng/dL went from 69.3% before treatment to 96.1% after. Full effect takes 1.5 to 2 months.
Source
These figures come from the Maximus Enclomiphene Protocol Study (N=1,250). The study design, the group-mean caveat, and the FDA limitation of use are set out in full under the dose table above, and the sources are listed in the References.
What gets measured
Five markers tell your doctor whether the dose is right
Enclomiphene dosing runs on blood work. Your doctor needs these five markers before your first pill:
- Total testosterone
- A free-testosterone measure, or the SHBG value used to calculate it
- Luteinizing Hormone (LH)
- PSA, a prostate marker
- Hematocrit, your red blood cell level
Blood work from the last 6 months counts if it covers all five. An LH below 1.0 IU/L points to a different cause of low testosterone, and a different protocol.
Timing and consistency
Best taken at the same time, every day.
One tablet a day, at the same time, keeps your levels steady while they build over 1.5 to 2 months.
Your prescription label carries the timing your physician set for you, and enclomiphene is taken once daily. Follow the label.
If you miss a day, message your care team, and do not change your dose on your own.
Where to start
Start with blood work, not with a dose
The best place to start is with a full testosterone-focused blood panel. This determines your baseline and helps your care team get the dosage dialed in over time.
Start with labs →Cost, insurance, and availability
The Maximus enclomiphene protocol runs $99.99 to $199.99 per month depending on plan length.* At current rates a 3-month plan totals $449.97 and a 12-month plan totals $1,199.88. New clients starting a 12-month plan get 50% off the first month. Lab testing is required, and any lab fee is disclosed in writing before your card is charged.
HSA and FSA eligible. 24/7 messaging with US-based, board-certified physicians. Compounded by LegitScript-certified US pharmacies.
Availability varies by state. Contact Maximus support to confirm eligibility where you live.
*Full billing, auto-renewal, and cancellation terms are below.
Compounded medications are not FDA-approved for safety, efficacy, or quality.
Your dose starts with a number only a blood test can give
You came here for a milligram figure. The honest answer is a range, and a board-certified doctor sets yours after reading your markers.
FAQ
Questions men ask about enclomiphene dosing
What is the standard enclomiphene dose for men?
There is no single standard. In the Maximus Enclomiphene Protocol Study (N=1,250), starting doses were 3.125mg, 6.25mg, or 12.5mg, titrated up to 25mg. A doctor sets yours from your markers, your symptoms, and your goals.
Can I adjust my own dose?
No. Every change is a physician decision. Your doctor reads your follow-up labs against your baseline and against how you feel, then changes the dose or holds it. Adjusting on your own also makes your next lab result hard to read.
What if I miss a dose?
Message your care team and do what they tell you. Do not double up, and do not change your dose on your own.
How long until my labs move?
The Maximus Enclomiphene Protocol Study collected follow-up blood 3 to 4 weeks after each dose change, and Maximus retests at 4 weeks. Full effect takes 1.5 to 2 months.
Is 25mg better than 12.5mg?
Not automatically. In the N=1,250 study, mean free testosterone rose more at 12.5mg than at 6.25mg, and the study reported no further rise above 12.5mg. 25mg was available to physicians titrating individual men, but higher is a clinical decision, not a default.
Does my enclomiphene dose change if I add Testosterone Cream?
It can. In the Maximus Topical T + Enclomiphene Study (N=45), men on Testosterone Cream took 12.5mg of enclomiphene or more. At that dose they held Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) above fertility thresholds. At 6.25mg those markers fell.
Do I need blood work before I start?
Yes. The lab test comes first and the dose comes from it. Blood work from the last 6 months works if it covers total testosterone, free testosterone, LH, PSA, and hematocrit. Your physician reviews what you have and orders any labs the protocol still needs.
Safety
Safety information
Enclomiphene's reported side effects come first. Maximus protocols can also include prescription testosterone, a different drug with its own class-wide safety profile, which follows it.
Important safety information: enclomiphene
Enclomiphene is a prescription medication and requires a physician evaluation. Reported side effects include headache, nausea, hot flashes, dizziness, mild gastrointestinal symptoms, mood changes, and mild acne. Visual disturbances are rare and warrant discontinuation and provider evaluation. Elevated liver enzymes are rare. Thromboembolism risk is a rare theoretical class effect shared with clomiphene. In the N=1,250 study, 80 treatment-emergent adverse events were observed among 75 voluntary withdrawals, with no serious adverse events.
Read full safety information
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Important safety information: testosterone therapy
Prescription testosterone requires a physician evaluation and ongoing lab monitoring. Reported effects across the class include acne or oily skin, libido changes, mood changes, fluid retention, elevated blood pressure, elevated hematocrit and hemoglobin, elevated PSA, testicular shrinkage, suppressed fertility, gynecomastia, and worsening of sleep apnea.
Serious risks include polycythemia or elevated hematocrit (CBC monitoring required), deep vein thrombosis and pulmonary embolism (rare), cardiovascular events in high-risk individuals, significant suppression of sperm production, and hypersensitivity reactions.
Read full safety information
Testosterone products carry a class-wide warning about increases in blood pressure, per FDA class-wide labeling changes announced February 28, 2025.
Topical secondary exposure. Testosterone Cream can transfer to another person through skin contact. Wash your hands after applying it and cover the application site with clothing. The site can be washed after 2 hours. Keep children and pets away from the site.
Injection-specific. Injection site pain, swelling, or bruising. Hypersensitivity to the oil carrier is rare. Injectable testosterone is a controlled substance.
Review the Medication Guide for any FDA-approved testosterone product your physician prescribes. Full safety information: maximustribe.com/safety
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
References
This page is general information about how supervised enclomiphene dosing works. It is not medical advice and it is not a dosing instruction.
- 01Maximus Enclomiphene Protocol Study (N=1,250). Sepah SC, Henry H, Alizaidy G, Boerger N. maximustribe.com/white-paper/enclomiphene
- 02Maximus Topical Testosterone with Enclomiphene Study (N=45). maximustribe.com/white-paper-testosterone-cream
- 03Kim ED, McCullough A, Kaminetsky J. Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement. BJU Int. 2016;117(4):677-685. doi.org/10.1111/bju.13337
- 04Earl JA, Kim ED. Enclomiphene citrate: a treatment that maintains fertility in men with secondary hypogonadism. Expert Rev Endocrinol Metab. 2019;14(3):157-165.
- 05Krzastek SC, Smith RP. Non-testosterone management of male hypogonadism: an examination of the existing literature. Transl Androl Urol. 2020;9(Suppl 2):S160. doi.org/10.21037/tau.2019.11.16
- 06Bhasin S, et al. Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men (Framingham Heart Study). J Clin Endocrinol Metab. 2011.
- 07Wiehle RD, Fontenot GK, Wike J, Hsu K, Nydell J, Lipshultz L; ZA-304 Trial Investigators. Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU Int. 2013;112(8):1188-1200. doi.org/10.1111/bju.12363
The pharmacokinetic source for the half-life on this page. 52 men were randomized to oral enclomiphene citrate at 12.5mg, 25mg, or 50mg, to topical testosterone gel, or to placebo, daily for 14 days. It reports rapid absorption, an elimination half-life of about 10 hours, and peak levels about 4 hours after a dose.
- 08Mulhall JP, Trost LW, Brannigan RE, et al. Evaluation and management of testosterone deficiency: AUA guideline. J Urol. 2018;200(2):423-432. doi.org/10.1016/j.juro.2018.03.115
The source for the 300 ng/dL threshold. Guideline Statement 1 (Moderate Recommendation, Evidence Level Grade B): clinicians should use a total testosterone level below 300 ng/dL as a reasonable cut-off in support of the diagnosis of low testosterone. The guideline also calls for two early-morning measurements on separate occasions, and it allows clinical judgment for men who have symptoms above 300 ng/dL. The 69.3% to 96.1% figures on this page come from the Maximus protocol study (citation 01), not from the AUA guideline.
Billing terms
Billed monthly on the 1-month plan, or paid in advance or in installments across the full term on the 3-month and 12-month plans. Auto-renews on the day your current term ends, at the plan price and cadence shown at checkout. Cancel by turning off auto-renewal in your Maximus dashboard at app.maximustribe.com/login or by emailing support@maximustribe.com, with no phone call required. Committed 3-month and 12-month plans run through the full term you agree to at checkout. They cannot be ended early, and the remainder of a committed term is not refundable.
Compounded medications are prepared by licensed 503A/503B pharmacies using pharmaceutical-grade active ingredients. They are not FDA-approved finished drug products. Maximus protocols require a physician prescription.
