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Jul 1, 2022

Why Should I Care About PT-141?

Studies have estimated that around 7 to 20 million men suffer from erectile dysfunction. In addition, erectile dysfunction becomes more common and more severe with age.

There is a clear relationship between sexual dysfunction and a poorer sense of wellbeing. A team of researchers wrote, “Sexual dysfunction, and erectile dysfunction in particular, is associated with an enormous burden of illness and poor quality of life.”

PT-141 (also known as bremelanotide) is a peptide that functions as a melanocortin agonist. In simple terms, this means that it is a compound that acts directly on melanocortin receptors in the central nervous system, increasing sexual arousal and performance. It activates the part of the brain that helps you get an erection when desired.

For the significant number of men who suffer from ED and other sexual dysfunction, PT-141 has been shown to be effective at improving performance. A clinical trial recruited men with erectile dysfunction who did not respond adequately to sildenafil (also known as Viagra). The results showed that the drug “resulted in a significant erectile response as compared to the placebo.”

Another study demonstrated that it can work synergistically with sildenafil to enhance erectile response without exacerbating the side effects of either medication.

Remember — sexual health is health. PT-141 ensures optimal sexual health so you can be ready and stay ready.

Disclaimer: This article is for informational purposes only. None of the content in this post should be taken as medical advice. Please discuss symptoms and health goals with your doctor.

References

Shadiack AM, Sharma SD, Earle DC, Spana C, Hallam TJ. Melanocortins in the treatment of male and female sexual dysfunction. Curr Top Med Chem. 2007;7(11):1137-1144. doi:10.2174/156802607780906681


Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res. 2004;16(2):135-142. doi:10.1038/sj.ijir.3901200

Diamond LE, Earle DC, Garcia WD, Spana C. Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response. Urology. 2005;65(4):755-759. doi:10.1016/j.urology.2004.10.060

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